Plasma concentration/time curve of erythromycin after a 12-hour intravenous infusion of erythromycin lactobionate in man

Plasma concentration/time curve of erythromycin after a 12-hour intravenous infusion of erythromycin lactobionate in man.

As the pharmacokinetics after a slow infusion had not previously been evaluated in the doses used in this study, it was decided to measure the plasma concentration/time curve after a twelve-hour intravenous infusion of 2-0 g of erythromycin lactobionate in 2 litres of 0.9/o normal saline. Six healthy medical students with no past history of cardiovascular, renal, hepatic, metabolic or gastroint...

Acute pancreatitis associated with infusion of erythromycin lactobionate.

Plasma bactericidal activity after administration of erythromycin estolate and erythromycin ethylsuccinate to healthy volunteers.

In a crossover design study, we compared the plasma bactericidal activities of erythromycin estolate (500 mg) and erythromycin ethylsuccinate (600 mg) after administration of a single oral dose to 12 healthy volunteers. Both erythromycin esters displayed very good plasma bactericidal activities against Streptococcus pneumoniae. The median bactericidal titers produced in plasma against Streptoco...

Accidental intravenous bolus infusion of potassium chloride in a young man with hypokalemic periodic paralysis

Hypokalemic periodic paralysis is anautosomal dominantdisease characterized by muscle weakness or paralysis with a matching fall in blood potassium levels. Paralysis attacks often occur in adolescence and are induced by strenuous exercise followed by rest, high carbohydrateor high sodiummeal content, sudden changes in temperature, and even excitement, noise, flashing lights and cold temperature...

Preparation and evaluation of a new erythromycin derivative -- erythromycin taurate.

Erythromycin taurate, a new derivative of erythromycin, was prepared by reacting erythromycin base with tauric acid and its physico-chemical and biological properties were evaluated. The derivative has reasonably good solubility in organic solvents. The partition coefficient values in chloroform/water 1.17 and octanol/water 1.16 systems indicate its good distribution in various tissues in vivo....